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KMID : 0438219750120030687
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Korea University Medical Journal
1975 Volume.12 No. 3 p.687 ~ p.694
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The Effects of γ-Aminobytyric Acid and Glycine on the Metabolism of Central Nervous System in Rat
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Abstract
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Neurophysiological research has suggested that certain naturally occurring amino acid possess transmitter properties in the mammalian central nervous system. It is known that 7-aminobutyric acid and glycine mimic natural inhibitory transmitters in the cerebral cortex, and brainstem and spinal cord, respectively. This experiment was carried out to investigate the metabolic function of gammaaminobutyric acid and glycine on central nervous system besides its role as a transmitter. The oxygen consumption rate of the slices of cerebral cortex_ cerebellum, thalamus, medulla oblongata, ventral and dorsal spinal cord in albino rat were determined using the Warburg´s manometric apparatus supplying 100% oxygen; with or without substrate in the Krebs-Ringer bicarbonate buffer medium (pH. 7.4)
The results are summarized as follows:
1. The dry weight of nervous tissue decreased as ascends. the neuraxis.
2. Gamma aminobutyric acid increased the oxygen consumption rate of cerebellum and thalamus respectively whereas decreased that of dorsal spinal. gray matter significantly.
3. The oxygen consumption rate of dorsal spinal grAy matter more significantly increased than ventral spinal gray-matter.
4. Glycine decreased the oxygen consumption rate of all the regions of brain whereas is inconspicuous in the spinal cord. According to results of the above findings, it may be speculated that gamma aminobutyric acid may be. utilized as oxydative substrate, while glycine can not be oxydized in the brain level. The metabolic effect is best seen in the spinal cord, where most cells are sensitive to both gamma-aminobutyric acid and glycine.
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